Mechanism

Immune Response

Adaptive and innate immune signaling that drives inflammation and shapes chronic skin disease.

Guideline

What it is

In atopic dermatitis, Th2-skewed responses (IL-4, IL-13, IL-31) dominate. In psoriasis, the IL-23 / Th17 / IL-17 axis predominates.

These pathway differences explain why systemic treatments target different cytokines for different conditions.

Distinguishing immune signatures is central to understanding why eczema and psoriasis look and behave differently despite both being inflammatory.

Innate immune response producing redness, swelling, and discomfort in affected skin.

Cell-to-cell signaling proteins (IL-17, IL-23, TNF, IL-4/13) that orchestrate skin inflammation.

Ingredient axes

Anti-inflammatory axis

General class — corticosteroids, calcineurin inhibitors, and similar agents — used in inflammatory skin disease.

Immune pathway targeting (Expert Mode)

Targeted antibodies and similar agents that modulate specific cytokine pathways in inflammatory skin disease.