Research
Each breakdown summarizes a guideline, review, or paper, tags the mechanisms it touches, and names its key limitations.
JAAD (Zaenglein et al.)
Synthesis of acne management evidence across topical and systemic axes. Anchors how mechanism-targeted ingredients map to clinical recommendations.
Limitations: Guidelines are updated periodically; specific recommendations evolve as evidence accumulates.
Open sourcePubMed (Borda LJ, Wikramanayake TC)
Reviews the three-facet model of seborrheic dermatitis (Malassezia, sebum, host susceptibility) and antifungal axes.
Limitations: A review summarizes existing evidence — it does not replace primary studies for any single claim.
Open sourceJID (Elias et al., literature)
Filaggrin’s role in barrier formation and NMF generation, and how variants interact with barrier-related inflammatory conditions.
Limitations: Variant frequencies and clinical relevance vary by population; not every barrier issue is filaggrin-related.
Open source