What it is
The skin barrier is the outer stratum corneum: corneocytes embedded in a lipid matrix of ceramides, cholesterol, and free fatty acids.
When this matrix is disrupted, transepidermal water loss rises, and irritants and microbes can interact more easily with deeper layers.
Barrier dysfunction is implicated in many inflammatory skin conditions, and supporting it is a recurring theme across dermatology.
Why it matters
A compromised barrier amplifies inflammation, irritation, and microbial response — a common downstream effect in both acne treatment and seborrheic dermatitis.