Mechanism
A self-reinforcing loop where itch drives scratching, which damages the barrier and inflames skin.
Itch in atopic skin is mediated by cytokines (notably IL-31), neuropeptides, and protease activity.
Scratching offers brief relief but mechanically damages the stratum corneum, releases more pro-inflammatory mediators, and amplifies the next itch episode.
Breaking the loop is a major theme in atopic dermatitis education and care.
Related
Stratum corneum + lipid matrix that controls water loss and limits irritant entry.
Innate immune response producing redness, swelling, and discomfort in affected skin.
Adaptive and innate immune signaling that drives inflammation and shapes chronic skin disease.
Ingredient axes